Medicinal Herbs and ADHD


The Endocannabinoid System

Key Topics:
July 23, 2020 • 1 min read

Defining the Endocannabinoid System

The endocannabinoid system (ECS) is a complex network of receptors, signaling molecules, and metabolic enzymes that most people do not know about. A building body of research shows that the ECS has a significant influence on human health and well-being, serving an essential function in the human body: restoring homeostasis via physiological and regulatory mechanisms. The ECS is made up of cannabinoid receptors, endocannabinoids, and metabolic enzymes.


From the discovery of the first phytocannabinoid, the endocannabinoid system has been of great interest to the scientific community for its nearly ubiquitous presence in the human body and its role in key physiological processes. This page serves as the hub for all information relating to hemp and the endocannabinoid system currently present in peer-reviewed scientific literature.

Structure of the Endocannabinoid System

What are endocannabinoids?

There are different types of cannabinoids. One type, called endocannabinoids, is produced on demand in the human body in response to elevated intracellular calcium levels in neurons. 

Two of the most-studied endocannabinoids include:

  • N-archidonylethanolamide (anandamide, AEA)
  • sn-z-archidonoylglycerol (2-AG).

What are cannabinoid receptors?

Cannabinoid receptors are the primary targets of the ECS, bound by lipid signaling molecules called cannabinoids. There are two main types of cannabinoid receptors, which vary in their chemical structure and thus perform different functions in terms of diet, lifestyle, and nutrition:

Cannabinoid Receptor 1 (CB1) is associated with various effects:

  • Psychoactive
  • Neuromodulatory
  • Analgesic

These effects are due to CB1’s activation by tetrahydrocannabinol (THC). Cannabinoid receptors in the brain are mostly expressed as CB1. CB1 is also found in adipocytes (fat cells), hepatocytes (liver cells), and musculoskeletal tissues.

Cannabinoid Receptor 2 (CB2) is associated with anti-inflammatory and immunomodulatory effects but no psychoactive effects. CB2 is expressed in body cells controlling immune function and (potentially) the central nervous system (CNS). Research suggests that secondary metabolites from phytonutrients in plant-based foods enhance the activity of CB2 receptors and confer healthy inflammatory responses.

Read more about endocannabinoid receptors:

Cannabinoid Receptors: CB1 and CB2

Cannabinoid receptors are the primary targets of the endocannabinoid system, bound by lipid signaling molecules called endocannabinoids.

Article • October 25, 2018• 3 min read BookmarkBookmark

Endocannabinoid System Activation

Everything you need to know about hemp, the endocannabinoid system, and omega-3 fatty acids

What are the major components of the endocannabinoid system (ECS)? How do omega-3 fatty acids and the ECS act synergistically? What are they key functions of the ECS in the human body? This helpful infographic provides a quick “ECS 101,” useful for a variety of educational situations. Download and print out your free copy today.

Download: View PDF

Role of the Endocannabinoid System

Endocannabinoid system receptors and cannabinoids are present and vital in nearly every area of the human body. Thus, disruption of the ECS has a serious, negative impact on human health. 

The ECS is responsible for basic homeostatic roles:

  • Relaxation
  • Metabolism
  • Sleep
  • Memory

The ECS is also responsible for more complex functions:

  • Neuroplasticity
  • Modulation of embryonic development
  • Neuroprotection
  • Immunity and inflammation
  • Apoptosis
  • Carcinogenesis
  • Pain and emotional memory

What is endocannabinoid tone?

The “endocannabinoid tone” describes as state of proper functioning of the ECS, which depends on the density, functional status, and availability of endocannabinoids. Endocannabinoid tone is influenced by multiple external factors, such as physical activity, eating a well-balanced diet of macronutrients, micronutrients, and phytonutrients, and stress modification. Whatever the reason, endocannabinoid deficiency prevents the ECS from properly regulating homeostasis in the body, but supplementation with phytocannabinoids can resolve some of these issues.

Learn more about how phytocannabinoids supplementation and nutrition interact in this article.

Nutrients Supporting the Endocannabinoid System

Hemp is rich with essential nutrients and bioactive phytochemical metabolites that nurture the endocannabinoid system.

Article • October 25, 2018• 3 min read BookmarkBookmark

We hope you have enjoyed this snippet from our Endocannabinoid System portal and that you are eager to learn more about the endocannabinoid system. Click here to read more and see related posts.

Scientifically driven. Education focused. Healing Inspired.

Subscribe to Insights

Receive clinically driven nutrition insights you can trust.

Animated Newsletter WM

Join Our Community to Read Further

This is a premium article created for our Healthcare Practitioner readers. Create a free account to continue reading and gain full access.



WholisticMatters offers health care practitioners and nutrition enthusiasts alike the opportunity to create a free profile for access to site features like bookmarking. Enjoying an article you are reading or a video you are watching? Save it to come back to later! Sign up in seconds for continuous access to all that WholisticMatters has to offer.

WholisticMatters also offers health care practitioners who create a free user profile access to exclusive content and tools to utilize in clinical practice. Articles, tools, and downloads created specifically for practitioners to use in their office for better patient education in clinical nutrition and health. Sign up today with your email and credentials so we can confirm you as a health care practitioner, and you are free to peruse the resources unique to you and your colleagues in health.


Create Your Account:

show-pass Please use 8 or more characters with a mix of letters, numbers & symbols

Create a free account to use our great bookmarking tool

Once your account is created, you'll be able to save and organize what matters to you!

Already have an Account? Login Here

Click 'Sign Up' above to accept Wholistic Matters's Terms of Service & Privacy Policy.

Are you a Healthcare Professional? Sign Up For Free Access!

We'll verify your credentials and get you access to our great interactive tools.

Already have an Account? Login Here

Click 'Sign Up' above to accept Wholistic Matters's Terms of Service & Privacy Policy.