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Scientific Name: Lentinus edodes

Constituents:

  • Myco-Polysaccharides (beta glucans: lentinan (β-1,3-glucan) & eritadenine)
  • Protein, Lipids & Fiber
  • Lectins

Medicinal actions:

  • Adaptogen
  • Anti-cancer
  • Antimicrobial
  • Hypocholesterolemic
  • Immune stimulant
  • Immunomodulator

Mechanism of Action & Pharmacology:

  • Polysaccharides (β-glucans) are well studied and appear to be primarily responsible for immune modulatory effects on both innate and adaptive immunity. May induce interferon production (thus disrupting viral replication & inhibiting bacterial infection), and upregulate the activity of macrophages, neutrophils, monocytes, natural killer, and dendritic cells. Also act as antigens playing a role in the first step of activation signaling pathways to antigen presenting cells.
  • Lentinan has immunomodulatory and anti-tumor effects, and appears to prolong the survival of cancer patients. Researchers working with terminal pancreatic cancer patients who responded positively noted an increase in killer T-lymphocytes and a decrease in levels of interleukin-6, granulocyte colony stimulating factor, and prostaglandin E2.
  • Eritadenine is an inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH) and has demonstrated hypocholesterolemic activity.

Pharmacy:

  • As food in soups, stews, broths and stir-frys
  • Powdered

Safety & Toxicity Concerns:

  • May experience mild diarrhea and digestive disturbance.

Interactions:

  • May decrease effectiveness of immunosuppressants.

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