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Scientific Name: Aesculus hippocastanum

Constituents:

  • Coumarins (esculin, aesculetin) & coumarin glycoside (aesculin)
  • Triterpene saponins (aescin = escin)
  • Flavonoids (quercetin and kaempferol), proanthocyanidin A2
  • Tannins (condensed & hydrolyzable)
  • Fatty acids
  • Sterols
  • Allantoin

Medicinal actions:

  • Anti-inflammatory
  • Antispasmodic
  • Anti-edematous
  • Astringent
  • Diuretic
  • Vasodilator
  • Venotonic & Vascular protective

Mechanism of Action & Pharmacology:

  • Aescin/escin is anti-inflammatory and a venous tonic. It inhibits hylauronidase, reduces fluid leakage and strengthens capillary cell membranes, thereby controlling bruising & edema. Other mechanisms include allowing improved entry of ions into channels, thus raising venous tension in both in vitro and in vivo conditions, release of PGF(2) from veins, antagonism to 5-HT and histamine, and reduced catabolism of tissue mucopolysaccharides.
  • Note: Aescin is a registered drug in Germany and the active ingredient in a number of preparations used either topically or orally for the treatment of peripheral vascular diseases, in particular those related to capillary permeability and resistance.
  • Flavonoids are anti-inflammatory and strengthen capillaries.
  • Aesculin (coumarin glycoside) found on the seeds needs to be removed from extracts as is toxic.

Pharmacy:

  • Capsules
  • Infusion
  • Tincture
  • Topical: wash, oil, cream, lotion, or poultice
  • Note: Short term or pause dosing required, 6 weeks due to hydrolyzable tannins

Safety & Toxicity Concerns:

  • High doses internally can cause nausea, gastrointestinal irritation and reflux.
  • Aescin has hemolytic properties, though is minimal within therapeutic doses. Past reports of acute renal failure from injection of b-aescin have revealed to be due to dosages much greater than manufacturer recommendations.
  • Avoid in known allergy, high or long-term doses, in children under 4, acute kidney inflammation, gastric ulcer, topical on broken or ulcerated skin (due to irritant effects of saponins), and IM injection of aescin.

Interactions:

  • May interfere with the binding of drugs to plasma proteins.
  • Aspirin or anticoagulants due to antiplatelet activity (theoretical).
  • With cardiac glycosides & phenopyrazine may cause calf spasm, fatigue, flushing, and pseudolupus.

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