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Scientific Name: Centella asiatica

Constituents:

  • Triterpenoid saponins (asiaticosides, madecassoside & brahmoside, brahminoside)
  • Nutrients (Vitamins K & B, Na, Ca, Mg)
  • Amino acids
  • Flavonoids (quercitin & kaempferol)
  • Volatile oils (Α-humulene, germacrene & β-caryphyllene)
  • Phytosterols (phytosterols (campesterol, sitosterol & stigmasterol)
  • Tannins
  • Mucilage
  • Resin
  • Alkaloid (hydrochotine)
  • Fatty acids (linoleic acids, linolnelic, oleic, palmitic and stearic acids).

Medicinal actions:

  • Adaptogen
  • Alterative
  • Anti-inflammatory
  • Bitter
  • Connective tissue builder
  • Diuretic
  • Nervine Tonic & Neuroprotective
  • Peripheral vasodilator
  • Vulnerary

Mechanism of Action & Pharmacology:

  • Triterpenoid saponins (asiaticoside) are vulnerary, anti-inflammatory, and considered to be responsible for anxiolytic effects. Will increase vascularization of connective tissue and the formation of structural glycosaminoglycans (chondroitin sulfate, hyaluronic acid).
  • Brahmoside is a diuretic. Along with brahminoside may be responsible for CNS depressant and reduced motor activities (yet to be confirmed by clinical studies).

Pharmacy:

  • Infusion
  • Tincture
  • Capsules
  • Topical as poultice, oil, lotion or salve

Safety & Toxicity Concerns:

  • Infusion: 1 tbsp/cup, infuse 10 min, TID.
  • Tincture: (1:5, 45%), 1-2 ml TID. Max 40 ml/week.
  • Capsules: 50-200 mg, TID, standardized to 40% asiaticosides.
  • Topical as poultice, oil, lotion or salve.
  • Pulse dose: 6 weeks on, 2 weeks off.

Interactions:

  • May inhibit efficacy of anti-diabetic agents & anti-hyperlipidemics.
  • May have additive effects with vasodilators, CNS depressants, and alter effects of GABAnergic medications.

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