Scientific Name: Eschscholzia californica
- Isoquinoline alkaloids (californidine, eschscholtzine, reticuline & chelerythrine)
- Flavone glycosides (rutin)
- Anxiolytic (lower doses)
- Nervine Relaxant & Sedative (hypnotic at higher doses)
Mechanism of Action & Pharmacology:
- Isoquinoline alkaloids are sedating, though are non-addictive and do not cause disorientation, and ethanol extracts have demonstrated binding to serotonin receptors 5-HT(1A) and 5-HT(7). Has also been shown to inhibit enzymatic degradation of catecholamines as well as the synthesis of adrenaline, dopamine b-hydroxylase and monoamine oxidase.
- Chelerythrine (an alkaloid constituent) is a protein kinase C inhibitor in the dorsal horn of the spinal cord, decreasing pain induced by heat or chemical stimulation.
- Flavone glycosides are antispasmodic and blood vessel tonics.
Safety & Toxicity Concerns:
- High doses may cause nausea and a residual hangover effect.
- Avoid in pregnancy & lactation due to unknown effects.
- Caution with nervous system medications (e.g. antidepressants & dopaminergic). May have additive effects when combined with other sedatives and barbituates.