Episode 14 – airs November 20, 2025 Why is it that women experience stress more intensely than men? Drs. Daina Parent and Annette Schippel discuss the connection between women’s hormones and the effects of stress on the female body. Dr. Schippel shares her personal and professional experience navigating the stages of a woman’s reproductive journey and how endocrine health plays a significant role in hormone balance. Drs. Parent and Schipple emphasize the importance of working with qualified healthcare providers trained in herbal medicine in order to find the right herbs for each person and symptom picture. Dr. Schippel offers invaluable clinical tools and takeaways to create a strong foundation for any woman to navigate stress management and optimal wellness with nutrition, herbs, lifestyle and more. Dr. Annette Schippel is a chiropractor and a graduate of Logan College of Chiropractic, she brings over 25 years of experience to her work. She owns two thriving family practices that focus on pediatrics, women’s health, and clinical nutrition, and she regularly sees patients from across the United States and around the world. Known for her expertise in functional medicine and endocrinology, Dr. Schippel has become a respected educator, author, and speaker. She has written and co-authored numerous clinician manuals and lectures domestically and internationally on topics in nutrition and functional endocrinology.  She has had the privilege of visiting Medi-Herb in Australia for 3 years to receive advanced training in phytotherapy.  She also had the honor to speak on alternative approaches to Metabolic Syndrome at the 2014 International Health Management Forum in Bejing China. Use the audio player above to listen now! And don’t forget to follow and like our podcast channel to stay up-to-date on upcoming episodes. Highlights of the episode include: Female hormones and stress sensitivity Adrenal burnout and perimenopause: the resiliency of the stress response affects hormone balance How herbs modulate and synergize with hormones Podcast Summary 2:24 Female hormones and stress sensitivity 4:00 The HPA Axis and the stress response 5:35 The thyroid adrenal connection 7:57 Cortisol, DHEA and the adrenal cortex 9:15 Prolactin, dopamine and high prevalence of autoimmunity in women 11:30 Key differences in male and female hormones: estradiol, testosterone, and DHEA 15:27 Peri- and menopausal hormone shifts 16:33 Adrenal burnout and perimenopause: the resiliency of the stress response affects hormone balance 21:13 Clinical strategies for adrenal support to mitigate perimenopausal symptoms – diet, exercise, sleep, digestion, and mental health 25:42 Herbs for adrenal support and endocrine balance – rehmania, ashwagandha, chaste tree, schizandra and more 29:33 How herbs modulate and synergize with hormones 30:02 Social media trends – perspectives on ashwagandha 33:06 Why guidance from a healthcare provider with herbal knowledge matters – finding the right herbs for each person 35:35 Choosing the right herb – how patient health history and symptom picture inform herbal selection 44:39 Using blood chemistry to inform patient protocols 45:55 Personalizing herbal protocols for different stages of the lifespan 48:38 Nutrients and herbs for libido and vaginal dryness and how adrenal resilience plays a role in these symptoms 50:32 Circulation, sexual health, and blood-flow support 52:53 Improving vasodilation through nitric oxide; whole foods and herbs that support circulation (beets, mountain spinach, red algae, and more) 54:45 Herbs as modulators – herbs won’t increase or decrease hormones too much 55:16 The truth about wild yam creams 58:54 The practitioner-patient journey – navigating better health together 1:01:51 Key clinical takeaway for supporting women’s health and stress management – how to build a good foundation and never lose sight of what you’re trying to build This podcast is sponsored by Standard Process About Standard Process – Only at SP https://youtu.be/06W6QnbDbSU?si=HhkXX9NerHPbhcDu

Physiology Meets Phytotherapy Any stressful situation, whether it is a family emergency, the deadline for a project, fear about losing a job, worry about not paying the bills on time, can trigger a cascade of signals in the body that release specific hormones that cause physiological changes in the body. This is known as the “fight” or “flight” response. These changes can manifest as a rapid heartbeat, sweat, tense muscles, headache, digestive problems, elevated body temperature, and more. Stress is the response to a real or perceived threat that disrupts the body’s homeostasis. The acute stress response is essential for survival, however, when the acute stress response is not shut off, there can be significant long-term health ramifications. As this acute response becomes prolonged, stress shifts from an adaptive reaction to a chronic condition. Chronic Stress and the HPA Axis Chronic stress occurs when there is prolonged exposure to stressful situations. This can be caused by long-term issues such as health problems, relationship issues, and problems at work. Overstimulation from technology and smart phones also contributes significantly to the overall increase in the experience of stress. Anxiety disorders have seen an 18.2% increase from 1990 to 2021 globally.1 Following Covid, over half of the population experienced emotional stress in 20 countries, and 85% of the countries reported worse psychological stress in 2020 compared with 2008.2 Chronic stress over time can wreak havoc in the body on your neurological health, hormone balance, and physical and mental health. Over time, this chronic stress can lead to Hypothalamic-Pituitary-Adrenal (HPA) axis dysfunction. The HPA axis consists of: Hypothalamus – the part of the brain responsible for regulating temperature, hunger mood, and more. It influences the autonomic nervous system and manages hormones. Pituitary gland – small gland located on the base of the brain below the hypothalamus. It makes essential hormones needed for the body and regulates other endocrine glands. Adrenal glands – small triangular shaped glands on the top of each kidney. They produce hormones like cortisol, aldosterone, and androgens that regulate blood pressure, stress response, metabolism, immune system, and sexual health. The adrenal glands also produce Epinephrine (the hormone that prepares the body for the flight or fight response) and norepinephrine. Cortisol Cortisol is a steroid hormone produced by the adrenals that is crucial to survival. It helps the body respond to stress, regulate blood sugar, metabolism, hormone regulation, and maintain blood pressure. The body is constantly producing, in varying concentrations throughout a 24-hour cycle. Typically, it is produced in higher amounts or stays elevated in those with a heightened fight/flight response. When cortisol levels rise significantly, it signals the hypothalamus to reduce the release of corticotrophin releasing hormone (CRH), which then leads to decreased ACTH production by the pituitary gland. High cortisol can inhibit and decrease production of other hormones like estrogen and progesterone which can lead to menstrual irregularities. Naturally cortisol levels should fluctuate throughout the day, being higher in the mornings and lower in the evenings. In the evenings, the body will produce melatonin and decrease cortisol production to facilitate a more restful state. In cases of chronic stress, cortisol can stay elevated for longer periods of time, and its patterns become more irregular. Herbal Remedies for Chronic Stress Given these physiological consequences, addressing chronic stress requires interventions that support both the nervous system and endocrine system. Herbal medicine can provide tremendous relief for those that experience acute or chronic stress. Numerous herbs have been utilized traditionally and effectively for managing both stress and anxiety. Herbs can be broken down into multiple therapeutic areas. Adaptogens Adaptogens, a term coined in the 1940’s, improve the body’s non-specific resistance to stress.3 Adaptogens accomplish this through their abilities to reduce oxidative stress, protect the mitochondria, normalize cortisol levels, and by regulating the HPA axis. Several adaptogens, including astragalus (Astragalus membranaceous), ashwagandha (Withania somniferum), licorice (Glycyrrhiza glabra), and rhodiola (Rhodiola rosea), have a long history of use in traditional herbal medicine for improving resilience to chronic stress, and have been shown in modern research to address multiple aspects of the stress response and more. Nervines Nervines are a category of plants that help to support the nervous system by relieving stress and helping to promote relaxation.4 Nervines, including lavender (Lavandula), skullcap (Scutellaria lateriflora), passionflower (Passiflora) and valerian (Valeriana officinalis) are plants that help to support the nervous system by relieving stress and promoting relaxation. Nervines are commonly used in conjunction with adaptogens due to the overlapping benefits. These work by acting on the central nervous system and peripheral nervous system to help improve overall resilience to stress.5 Nervines are categorized by nervine tonics, nervine relaxants, and nervine stimulants. Nervines typically have a fast-acting effect on the nervous system, making them more appropriate for addressing acute stress, while adaptogens work at a deeper level to support nervous system homeostasis. Nervine Spotlight on Skullcap Within these categories, several herbs stand out for their synergistic potential. Skullcap (Scutellaria Lateriflora), commonly known as “blue skullcap” and “American skullcap” is hardy perennial herb that belongs to the mint family (Lamiaceae), and is native to North America. Its traditional uses dates to the Indigenous people of North America who traditionally consumed it as a tea to help soothe nerves, as a sedative, and anticonvulsant.6 Today in western herbal medicine, skullcap is utilized to help relieve nervous tension, anxiety, combat insomnia, neuralgia, and epilepsy.7 Skullcap aerial parts consist of phytochemicals like flavonoids, glycosides, cinnamic acid and caffeic acid.6 Skullcap acts as a nervine tonic, spasmolytic and in higher doses, a sedative. It can have restorative effects on the nerves, physically and mentally/emotionally.  One study summarized key findings of a significant sleep-wake balance improvement when supplemented with Skullcap in a controlled, randomized, crossover double blind clinical trial.8 Adaptogenic Actions of Licorice Transitioning from nervines to adaptogens, licorice root is an adaptogen that has historically been used forbronchitis, throat infections, liver diseases, gastritis, peptic ulcerations, and adrenal insufficiency.7,9 It has a long history of use in traditional Asia and European herbal medicine and has since been commercially grown all over the world due to its multitude of uses in food, cosmetics, and pharmaceuticals.10 Transitioning from nervines to adaptogens, licorice root is an adaptogen that has historically been used forbronchitis, throat infections, liver diseases, gastritis, peptic ulcerations, and adrenal insufficiency.7,9 It has a long history of use in traditional Asia and European herbal medicine and has since been commercially grown all over the world due to its multitude of uses in food, cosmetics, and pharmaceuticals.10 Licorice’s main medicinal properties act as an anti-inflammatory, expectorant, demulcent, anti-microbial, and adrenal tonic. Licorice’s main key constituents consist of: saponins, glycyrrhizin (glycyrrhizic acid) present in the form of potassium and calcium salts and flavonoids.7 In animal models, licorice root was studied and noted to reduce anxiety and fear in post-traumatic stress disorder subjects.11 Glycyrrhizin from licorice root has been shown to contain antioxidant, anti-inflammatory, and immune regulatory actions.12 Adaptogen Spotlight on Ashwagandha Another cornerstone adaptogen, ashwagandha, has a long historical use as an adaptogen to strengthen the nervous system and combat stress. Ashwagandha holds therapeutic properties as a mild sedative, anti-inflammatory, immune modulating, neuroprotective, and anti-microbial.13 Its medicinal uses trace back to Indian medicine over 3,000 years ago.14 Traditionally, it has been used as an aphrodisiac, narcotic, tonic, diuretic, anthelmintic, and stimulant. It is naturally native in India but due to its current widespread popularity, it is now grown in many parts of the world.15 Another cornerstone adaptogen, ashwagandha, has a long historical use as an adaptogen to strengthen the nervous system and combat stress. Ashwagandha holds therapeutic properties as a mild sedative, anti-inflammatory, immune modulating, neuroprotective, and anti-microbial.13 Its medicinal uses trace back to Indian medicine over 3,000 years ago.14 Traditionally, it has been used as an aphrodisiac, narcotic, tonic, diuretic, anthelmintic, and stimulant. It is naturally native in India but due to its current widespread popularity, it is now grown in many parts of the world.15 Ashwagandha contains withanolides, alkaloids, and flavonoids.13 A recent study displayed that ashwagandha root extract may help improve sleep quality and sleep onset latency in patients with insomnia.16 Multiple studies have found that standardized ashwagandha root extracts reduce perceived stress, anxiety and lower cortisol when compared to placebos.16-18  Recent trials have shown improvements in endurance, strength and recovery in healthy adults and athletes using specific ashwagandha extract formulations. 19 Korean Ginseng as Adaptogen and Tonic Herb Korean ginseng has been traditionally used for athletic and psychomotor performances, depression, and sexual function.7 Its main actions include: adaptogenic, tonic, immune modulating, cardiotonic, male tonic, cancer preventative, and cognition enhancing.7 The key constituents of ginseng include a complex mixture of saponins, ginsenosides, oleanolic saponin, polysaccharides, and essential oils. Korean ginseng has been traditionally used for athletic and psychomotor performances, depression, and sexual function.7 Its main actions include: adaptogenic, tonic, immune modulating, cardiotonic, male tonic, cancer preventative, and cognition enhancing.7 The key constituents of ginseng include a complex mixture of saponins, ginsenosides, oleanolic saponin, polysaccharides, and essential oils. Ginsenosides, the main phytochemical of ginseng, has been studied for its anti-inflammatory and antioxidant properties in cell and animal models by modulating NF-kB and JAK/STAT pathways.20 Several small, randomized controlled trials found modest improvements in attention and working memory.21 Additional studies have been conducted to study ginseng and its role in fatigue, physical performance, and its cardiometabolic effects.22,23 Clinical Takeaways Chronic stress represents one of the most pervasive disruptors of physiological balance, influencing the HPA axis, hormone regulation, and overall neurological resilience. A combination of nervines and adaptogens offers a powerful therapeutic strategy. Nervines such as skullcap provide rapid relief of nervous tension, calming the hyperactive sympathetic response and promoting relaxation, while adaptogens like Ashwagandha, licorice root, and Korean ginseng, work more deeply to restore HPA axis function, regulate cortisol, and build long-term resilience to stress. In a clinical setting, this synergistic partnership allows for both immediate soothing of the nervous system and gradual rebalancing of hormonal and metabolic function. Together, these herbs bridge acute symptom relief with long-term adaptation, offering a holistic, evidence-informed approach to managing modern stress in all its physiological and psychological challenges.   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Turnip greens come from the leaves of root vegetable Brassica rapa subsp. rapa and are a particularly rich source of vitamins K, E, and B6 as well as plant form folate and phytoactive compound lutein. The dry leaves from turnips are also a rich source of glucosinolates and the activating enzyme myrosinase. Key Nutrients in Turnip Greens Percentages shown as %DV per serving of 5.68g turnip greens. Total Phenolic Concentration in Turnip Greens Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Turnip Greens Glucosinolates Sulfur-containing secondary metabolites mostly found in cruciferous vegetables, when activated by myrosinase from the plant or after ingestion by gut bacteria, associated with positive effects stemming from antioxidant activity such as cardio-protection and detoxification support Other Glucosinolates (4.12 mg/g)** Neoglucobrassicin (1.74mg/g)** Glucoraphasatin (1.2 mg/g)** Glucobrassicanapin (1.06 mg/g)** Flavonols Promote antioxidant activity and vascular health Kaempferol (31.7 mcg/g)* Quercetin (4.9 mcg/g)* Phenolic Acids Phytoactive compounds that promote anti-oxidant activity and vascular health Caffeic Acid(29.5 mcg/g)* Gallic Acid (23.1 mcg/g)* Ferulic Acid (6.0 mcg/g)* Protocatechuic Acid (6.0 mcg/g)* Myrosinase Enzyme found in plant tissue that initiates conversion of glucosinolates to bioactive isothiocyanates Ellagic Acid Potential antioxidant compound with anti-cancer potential Chloryphyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Carotenoids Antioxidants with anti-cancer potential and may lower risk of macular degeneration Beta-carotene(220.8 mcg/g)** *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Dark leafy greens with vibrantly colored stems and veins are trademark features of Swiss chard (Beta vulgaris subsp. cicla). This plant is a mineraldelivery powerhouse. Key Nutrients in Swiss Chard Percentages shown as %DV per serving of 5g dry Swiss chard extract. Total Phenolic Concentration in Swiss Chard Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Swiss Chard Chlorophyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Flavonols Promote antioxidant activity and vascular health Kaempferol(92 mcg/g)* Quercetin(75 mcg/g)* Myricetin(22 mcg/g)* Lignans Cross-linked phenolic compounds that make up plant cell walls and are insoluble fibers that aid in fecal bulking and feed some gut bacteria Secoisolariciresinol   (0.07 mcg/g)* Betalains Natural pigments with antioxidant, anti-cancer, anti-lipidemic, and antimicrobial properties Betacyanins Betaxanthins Carotenoids Antioxidants with anti-cancer potential and may lower risk of macular degeneration Lutein  (1.45 mg/g)** Zeaxanthin(10.6 mg/g)** Beta-carotene (52.26 mg/g)** *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Spanish Black Radish (Raphinoussativus L. Var. niger) is a cruciferous vegetable associated with the production of detoxification enzymes, healthy digestion, and healthy liver and gallbladder function. Spanish black radish is grown for its rich supply of glucosinolates. Key Nutrients in Spanish Black Radish Percentages shown as %DV per serving of 5.5g Spanish black radish. Total Phenolic Concentration in Spanish Black Radish Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Spanish Black Radish Glucosinolates Sulfur-containing secondary metabolites mostly found in cruciferous vegetables, when activated by myrosinase from the plant or after ingestion by gut bacteria, associated with positive effects stemming from antioxidant activity such as cardio-protection and detoxification support Glucobrassicin (11.835 mg/g)** Sinigrin (0.215 mg/g)** Gluconapin (0.2 mg/g)**Glucoraphanin (0.12 mg/g)** Glucoerucin (0.095 mg/g)** Glucobrassicin (0.082 mg/g)** Glucobrassicanapin (0.058 mg/g)**Glucoraphenin (0.004 mg/g)** Neoglucobrassicin (0.002 mg/g)**4-MeOH Glucobrassicin (0.002 mg/g)** Saponins Compounds that support the immune system, healthy cholesterol levels, and blood glucose levels Tanins Large set of diverse phenolic compounds found in plants that contribute to antioxidant activity, antimicrobial action, and distinct dark color  Myrosinase Enzyme found in plant tissue that initiates conversion of glucosinolates to bioactive isothiocyanates Fiber Supports cardiovascular health, healthy bowel function, and healthy cholesterol levels *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

The squeezed juice from the combined pods, vines, leaves, and stems of the common pea (Pisum sativum) is a nutritionally packed source of essentialvitamins and a significant source for phenolic compounds. Key Nutrients in Peavine Percentages shown as %DV per serving of 5g peavine juice extract. Total Phenolic Concentration in Peavine Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Peavine Chlorophyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Flavonols Phenolic acids exclusive to oats with antioxidant and anti-inflammatory activities and a bitter perception Kaempferol Catechin (0.1 mcg/g)*Epicatechin (0.1 mcg/g)* Epigallocatechin Gallocatechin Lignans Large plant polyphenolic compounds that bypass human digestion, feed gut bacteria, and provide antioxidant activity Lariciresinol (0.5 mcg/g)* Pinoresinol (0.07 mcg/g)* Syringaresinol (0.04 mcg/g)*  Medioresinol (0.035 mcg/g)* Secoisolariciresinol (0.00756 mcg/g)* Phenolic Acids Compounds that promote antioxidant activity and vascular health Sinapoyl-glucoside Saponins Support the immune system, healthy cholesterol levels, and blood glucose levels Soyasaponin I Soyasaponin ßg Carotenoids Antioxidants with anti-cancer potential and may lower risk of macular degeneration Lutein (7.22 mcg/g)** Zeaxanthin (0.39 mcg/g)** *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Oats (Avena sativa) are a widely consumed grain product as a rolled whole oat or ground into flour. They deliver a healthy source of energy paired with phenolic compounds, essential nutrients, soluble and insoluble fibers. Intake of soluble fibers from grain oats has been linked to reduced risk of cardiovascular disease (CVD). Top oat varieties include increased levels of phytochemicals and provide beneficial fibers.  Key Nutrients in Oats Percentages shown as %DV per serving of 30g oats. Total Phenolic Concentration in Oats Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Oats Fiber Supports cardiovascular health, healthy bowel function, and healthy cholesterol levels Beta-glucan (56 mcg/g)**  The main soluble fiber in oats connected to reduced CVD risk Arabinoxylan Type 1 Resistant Starch  Avenanthramides Phenolic acids exclusive to oats with antioxidant and anti-inflammatory activities and a bitter perception Avenanthramide C (49.24 mcg/g)* Avenanthramide B (31.85 mcg/g)* Avenanthramide A (31.67 mcg/g)* Avenanthramide E (0.15 mcg/g)* Lignans Large plant polyphenolic compounds that bypass human digestion, feed gut bacteria, and provide antioxidant activity Syringaresinol (3.5 mcg/100g)*  Lariciresinol (1.8 mcg/100g)* Matairesinol (0.7 mcg/100g)*Medioresinol (0.4 mcg/100g)* Secoisolariciresinol (0.1 mcg/100g)* Pinoresinol (0.08 mcg/100g)* Phenolic Acids Compounds that promote antioxidant activity and vascular health 4-Hydrobenzoic Acid  (4.5 mcg/g)* Vanillic Acid  (2.7 mcg/100g)* Ferulic Acid (1.9 mcg/100g)* p-Coumaric Acid  (1.6 mcg/100g)* Hydrobenzaldehyde (1.2 mcg/100g)* Sinapic Acid (0.4 mcg/100g)* Flavanones Colorless flavonoid compounds with antioxidant activity Neohesperidin (6.2 mcg/g)* Saponins Support the immune system, healthy cholesterol levels, and blood glucose levels Avenacoside A Avenacoside B *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

The material of the common bean (Phaseolus vulgaris) is rich with iron, magnesium, folate, fiber, and thiamin, among other macro- and micronutrients. The sprouts and full-grown plant contain ample amounts of essential minerals, various vitamins, and phenolic compounds. Key Nutrients in Kidney Bean Percentages shown as %DV per serving of 5g kidney bean juice extract. Total Phenolic Concentration in Kidney bean Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Kidney Bean Saponins Support the immune system, healthy cholesterol levels, and blood glucose levels Bayogenin Soyasaponin I Soyasaponin V Chlorophyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Lignans Large plant polyphenolic compounds that bypass human digestion, feed gut bacteria, and provide antioxidant activity Lariciresinol (1.2 mcg/g)* Secoisolariciresinol (0.8 mcg/g)* Pinoresinol (0.3 mcg/g)* Syringaresinol (0.08 mcg/g)*  Phenolic Acids Compounds that promote antioxidant activity and vascular health Ferulic Acid (128.4 mcg/g)* Sinapic Acid (51.7 mcg/g)* p-Coumaric Acid  (38.1 mcg/g)* Coumaroyl-malate Feruroyl-malate Isoflavonoids Phenolic compounds with direct antioxidant effects Genistein (2.0 mcg/g)* Flavonols Promote antioxidant activity and vascular health Kaempferol-3-O-glucoside (398.8 mcg/g)* Quercetin-3-glucoronide2(286 mcg/g)* Kaempferol-3-O-acetyl-glucoside (164 mcg/g)* Kaempferol-3-O-xylosyl-glucoside (115 mcg/g)* Kaempferol (12.2 mcg/g)*Quercetin (6.8 mcg/g)* Kaempferol-3-glycoside Kaempferol-3-O-rutinoside Quercetin-3-acetyl-glycoside Quercetin-3-glycoside Rutin *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Brussels sprouts (Brassica oleracea var. gemmifera) are a cruciferous vegetable associated with production of detoxification enzymes, antioxidant properties, cardiovascular protection, and anti-carcinogenic activity. Brussels sprouts are a staple vegetable in healthy diets, grown for their rich supply of glucosinolates and nutrients. Key Nutrients in Brussels Sprouts Percentages shown as %DV per serving of 21.4g Brussels sprouts. Total Phenolic Concentration in Brussels Sprouts Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Brussels Sprouts Flavones Compounds with anti-inflammatory, antimicrobial, and anti-cancer activity Luteolin (1.7 mcg/g)* Carotenoids Antioxidants with anti-cancer potential and may lower risk of macular degeneration Beta-carotene(30.2 mcg/g)** Lutein (11.8 mcg/g)** Supports exercise performance and cardiovascular health Chlorophyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Fiber Supports cardiovascular health, healthy bowel function, and healthy cholesterol levels Arabinoxylan Lignans Cross-linked phenolic compounds that make up plant cell walls and are insoluble fibers that aid in fecal bulking and feed some gut bacteria Lariciresinol (493 mcg/g)* Pinoresinol(220 mcg/g)* Secoisolariciresinol(10.6 mcg/g)*  Myrosinase Enzyme found in plant tissue that initiates conversion of glucosinolates to bioactive isothiocyanates Glucosinolates Sulfur-containing secondary metabolites mostly found in cruciferous vegetables, when activated by myrosinase from the plant or after ingestion by gut bacteria, associated with positive effects stemming from antioxidant activity such as cardio-protection and detoxification support Glucobrassicin (0.61 mg)** Glucoiberin(0.45 mg)** Sinigrin (0.37 mg)** Progoitrin (0.12 mg)** Glucoraphasatin(0.11 mg)** Glucoraphanin (0.10 mg)** Gluconapin(0.07 mg)**   Flavonols Promote antioxidant activity and vascular health Kaempferol (9.5 mcg/g)* Quercetin(3.0 mcg/g)* *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Barley (Hordeum vulgare) is grown primarily for its cereal grain, but the grass portion of the plant provides a rich source of minerals and B vitamins, like riboflavin and biotin. Key Nutrients in Barley Grass Percentages shown as %DV per serving of 5g barley grass extract. Total Phenolic Concentration in Barley Grass Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Barley Grass Flavones Compounds with anti-inflammatory, antimicrobial, and anti-cancer activity Cynaroside Isoorientin Isovitexin Luteolin Luteolin-3-7-di-glucoside Orientin Vitexin Chlorophyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity Fiber Supports cardiovascular health, healthy bowel function, and healthy cholesterol levels Arabinoxylan Phenolic Acids Compounds that promote anti-oxidant activity and vascular health Chlorogenic Acid Ferulic Acid Flavonols Compounds with anti-inflammatory, antimicrobial, and anti-cancer activity Lutonarin Saponarin *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More