Root Cause of Common Digestive Complaints Common digestive issues such as heartburn/acid reflux, bloating, gas, indigestion, and nutrient-specific deficiencies occur if digestion is somehow altered or otherwise impaired. Many believe this is related to high levels or excessive production of stomach acid, or hyperchlorhydria, and take over-the-counter antacids or prescription Proton Pump Inhibitors (PPIs) to suppress the acid and alleviate some of these signs and symptoms.1 When this normally acidic environment is suppressed, or buffered, to a higher pH, gaseous acid bubbles are formed, creating the feeling of gas pressure, bloating, upset stomach, or the need to belch. Furthermore, if these bubbles come in contact with the esophagus, it may be experienced as acid reflux and/or heartburn. Rather than an over-production of stomach acid, these signs and symptoms are indicative of insufficient stomach acid, or hypochlorhydria.2 Hypochlorhydria: Insufficient Stomach Acid Hypochlorhydria has been linked to chronic inflammation of the stomach, chronic stress, H. Pylori infection, gastritis, pancreatitis, obesity, gastric-bypass surgery, as well as different autoimmune diseases, alcoholism, cirrhosis, hypertension, chronic over-use of antacids or PPIs, and aging.2,3 Regardless of the etiology, the resulting effect is the same – the stomach-acid producing and secreting cells atrophy and die off.1,2 With excessive suppression of the stomach acid, the resiliency and functionality of the stomach, digestive system, and immune system are compromised. For example, when stomach acid is suppressed, the first line of defense against stealth pathogens is disrupted and the stomach becomes more susceptible to infectious bacteria like H. Pylori. This often snowballs and leads to chronic inflammation of the stomach, or gastritis, as well as stomach ulcers, SIBO, and other bacterial overgrowths.4 Additionally, studies show the stomach operates at an optimal pH range of 1.0-2.0, while hypochlorhydria would present with a resting pH of >3.0, and regular use of antacids and PPIs have demonstrated a resting stomach pH 5.0-7.0.4 Therefore, the stomach requires more acid to lower the pH into optimal operating range so to better facilitate digestion, nutrient absorption, and general immune health.4,5 Digestion of Protein As digestion is the physical and chemical alteration of ingested food into smaller, more soluble particles, it is required to facilitate proper nutrient absorption. The stomach in particular is responsible for the digestion of protein such as eggs, meat, dairy, legumes, nuts, and seeds. When protein reaches the stomach, specific cells- called parietal cells, secrete stomach acid, or HCl, to support digestion. With optimal levels of stomach acid, the lowered pH denatures or unfolds the complex 3D structure of protein into a single, long protein chain, allowing for easier cleavage into short protein chains called polypeptides or single protein building blocks- amino acids.1,4,6 This happens optimally at a pH around 1.8-3.5, is especially useful for the digestion of muscle tissue and other collagen containing meat components, and is rendered inert at a higher, more alkaline pH.7 Without proper acidic conditions and without proper denaturation of the proteins, the protein molecules may not be small enough to be absorbed by the intestines, which in turn may contribute to food allergies, protein deficiency, impaired protein and DNA synthesis, and micronutrient deficiencies – specifically  iron, zinc, and B12, which are largely obtained from animal sources.4 Protein-Specific Digestive Enzymes The acidic conditions are also needed to activate the protein-specific digestive enzymes such as pepsin, which is responsible for a majority of the protein cleaving action.4 Additionally, stomach acid and other gastric secretions further facilitate the solubility, and absorption, of additional micronutrients such as vitamin C, E, B6, B12, folic acid, iron, calcium, magnesium, zinc, and copper through various, often complex, mechanisms.1,8,9 As an acidic environment is necessary for the absorption of such micronutrients, the occurrence of nutrient deficiencies is highly correlated with the occurrence of hypochlorhydria and may present as poor skin/hair/nails and slow wound healing, waning of the eyes, heart, or memory, chronic fatigue, chronic inflammation, muscle cramps/spasms, tingling in limbs, high blood pressure, and a high risk of bone fracture.1,2,4,8,9  Furthermore, if food isn’t properly digested, this may lead to, or further exacerbate, lower GI and/or elimination issues.2,10   Testing for Hypochlorhydria As the signs and symptoms of hypochlorhydria are similar to hyperchlorhydria, the best way to tell if additional stomach acid is needed is to test for it. While there are a handful of specialized tests that a Gastroenterologist can order to test pH, secretion levels, etc, there is a quick at-home test as well. Per the Cleveland Clinic: “Drink half a glass (4 ounces) of cold water combined with a quarter teaspoon (1/4 tsp) of baking soda, on an empty stomach.” The baking soda will combine with the resting level of stomach acid and produce carbon dioxide, or gas bubbles. The gas bubbles will induce burping, if a burp surfaces within 3-5 minutes, then the stomach is sufficiently acidic. If it takes longer than 5 minutes, stomach acid is low and likely requires reacidification support.2 More sophisticated testing would be appropriate if there are any suspected nutrient deficiencies, food allergies, or other bacterial overgrowths.  Digestive Remedies and Interventions to Aid in Stomach Reacidification Additionally, if stomach acid is determined to be low, there are simple interventions that would help support stomach reacidification and digestion, these include: Sucking on or eating something sour before meals Eating protein components of the meal first Again, the arrival of protein in the stomach naturally triggers the secretion of stomach acid Chewing thoroughly This creates more surface area and further supports protein unfoldment Eating fermented foods That support a comprehensive and healthy microbial environment Drinking fluids later in the meal This allows time for the acid to work without being buffered or diluted Acid replacement therapy or supplementation with betaine HCl Supplementation with Betaine HCl Studies have shown betaine HCl to have a relatively immediate effect on stomach reacidification, within 10 minutes of ingestion. The effect has been demonstrated to last around 75 minutes, which provides ample time for specific micronutrients and pH-dependent drugs to become more soluble for absorption.5 Additionally, studies have also shown that the body’s natural response to certain physiological cues decrease with age, so the elderly population may benefit from taking betaine HCl before a meal to preemptively acidify the stomach where the body’s natural response system may be slow to action and limit digestion.4 Pepsin Supplementation To further facilitate the digestion of protein, additional supplementation of the stomach-specific enzyme pepsin, which is activated by acidic conditions, may also be warranted as it contributes to specific peptide cleavage, where these cleaved amino acids trigger other essential digestive activities, and further promotes nutrient absorption.2,11 In fact, the signaling activities of pepsin are thought to be more critical to digestion than its protein cleaving action as it triggers other digestive secretions, hormone signaling, and proper gastric emptying. Furthermore, pepsin itself has been shown to alleviate dyspeptic, or stomach acid, imbalances and is widely used  in combination with betaine HCl to correct hypochlorhydria.11 However, a strong acidic environment and other beneficial stomach enzymes are still not enough to completely digest protein or the shorter polypeptide chains. As protein accounts for around 10% of our caloric intake and is needed for wound repair, tissue healing, growth and development, energy, and DNA synthesis, our body needs additional support to be able to absorb these protein-specific nutrients and amino acids in totality.7 Digestive Enzymes Secreted by the Pancreas After the contents are released from the stomach into the first part of the small intestine, or the duodenum, the pancreas first secretes bicarbonate to buffer the acidified stomach contents. The pancreas then secretes additional digestive enzymes, which are only effective in a more buffered, or basic, solution. Of the digestive enzymes secreted, 80% are proteases, or enzymes such as pancreatin that will specifically assist the digestion of protein. The additional 20% of the pancreatic digestive enzymes support the digestion of the other macronutrients – carbohydrates and fat. 7,12   Pancreatin Pancreatin, in particular, finishes the hydrolysis process by fully transforming the bulky protein molecule, or peptide chain, into single amino acids and further promotes total macronutrient absorption .7 Without this major component of enzymes, protein goes largely undigested, the other macronutrients go unabsorbed, tissue growth and repair is inhibited, and nutrient deficiencies are common.12 Therefore, additional digestive enzyme supplementation may also be supportive if signs and symptoms, such as fatigue, slow wound healing, nerve/muscle pain, frailty and/or other bone-related concerns, are present independently or in combination with other GI concerns. Clinical Takeaways Digestive concerns, such as acid reflux, heartburn, gas, bloating, and belching, are synonymous with dyspepsia and assessing stomach acid levels may be worthwhile to better facilitate and improve (protein) digestion, and ultimately, absorption. If testing confirms hypochlorhydria, supplementing with betaine HCl would be beneficial to promote stomach reacidification and digestion. Digestive remedies such as betaine HCl, further fortified with pepsin and pancreatin, would then support a highly acidic environment, appropriate and healthy digestive signaling, nutrient absorption, and immune health, while addressing and alleviating other common digestive symptoms, malabsorption, and nutrient deficiencies.   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Episode 15 – airs December 4, 2025 Dr. Sarah Clarke, DC, IFMCP, and Dave Hogsed, DOM, AP,  discuss traditional and cultural trends around the consumption of organ meats, and the nutritional value these foods offer. They cover nutrients found various organ meats and how they can either be eaten or taken in supplement form. Dave shares clinical success stories, including his own personal experience, using organ meat glandular therapy. He explains how various organ and glandular meats can support immune function, cardiovascular health, nervous system health, cognitive function, bone health, and more. David Hogsed, DOM, AP, is in full time practice at the Natural Healthcare Professionals clinic in Fort Myers, Florida. His practice specializes in providing effective nutritional support for endocrine, digestion, musculoskeletal, nervous system, and immune system health. David has been a clinical consultant and speaker for Standard Process since 2003. His seminars are best known for simplifying clinical nutrition, herbal medicine, laboratory tests, and patient education. David has taught post-graduate programs through Texas Chiropractic College, Logan Chiropractic College, the University of Miami-Miller School of Medicine, Palmer Chiropractic College, Life University, and Northwestern Chiropractic College. He is a regular speaker for the Florida Chiropractic Association, and Palmer Chiropractic College homecoming. Use the audio player above to listen now! And don’t forget to follow and like our podcast channel to stay up-to-date on upcoming episodes. Highlights of the episode include: Organ Meats: the forgotten superfoods – historical consumption around the world Liver: the most nutrient dense organ meat Studies and historical evidence of health benefits of organ meats Podcast Summary 2:40 Dave’s first personal success story with organ meat glandular therapy 5:15 Clinical results from combining organ meat supplements with herbal and nutritional support 7:06 Organ Meats: the forgotten superfoods – historical consumption around the world 8:50 Traditional Chinese Medicine – consumption of organ would support that organ 9:48 Liver: the most nutrient dense organ meat 12:04 Returning popularity of other traditional foods – raw sauerkraut, bone broths, cod liver oil, and more 12:46 Foods essential for health – “you must take it (as a supplement) or eat it” 14:00 Tips for incorporating liver into your diet 15:03 Key benefits of bone broth and bone extracts 16:53 Animals instinctively know the health benefits of organ meats 18:06 The consumption of heart for cardiovascular health 21:30 Combating the effects of stress with organ meats: liver and adrenal glandular extract 23:30 Studies are now finding additional nutritional benefits in organ meats – mRNA 24:21 Nutritional difference between skeletal muscle meat vs. organ meat 27:24 Studies and historical evidence of health benefits of organ meats 28:17 Liver: the ultimate multivitamin 31:00 Organ meats for immune support – thymus extract 32:40 Historical consumption of brain around the world for cognitive health 34:49 Testicular and ovarian extracts for hormone regulation 35:40 The importance of thymus extracts in young children and with aging populations 36:46 Liver is the king of organ meats This podcast is sponsored by Standard Process About Standard Process – Only at SP https://youtu.be/xvFpIr2ctgE?si=mx-9S1UGDD8IKIDw

Episode 14 – airs November 20, 2025 Why is it that women experience stress more intensely than men? Drs. Daina Parent and Annette Schippel discuss the connection between women’s hormones and the effects of stress on the female body. Dr. Schippel shares her personal and professional experience navigating the stages of a woman’s reproductive journey and how endocrine health plays a significant role in hormone balance. Drs. Parent and Schipple emphasize the importance of working with qualified healthcare providers trained in herbal medicine in order to find the right herbs for each person and symptom picture. Dr. Schippel offers invaluable clinical tools and takeaways to create a strong foundation for any woman to navigate stress management and optimal wellness with nutrition, herbs, lifestyle and more. Dr. Annette Schippel is a chiropractor and a graduate of Logan College of Chiropractic, she brings over 25 years of experience to her work. She owns two thriving family practices that focus on pediatrics, women’s health, and clinical nutrition, and she regularly sees patients from across the United States and around the world. Known for her expertise in functional medicine and endocrinology, Dr. Schippel has become a respected educator, author, and speaker. She has written and co-authored numerous clinician manuals and lectures domestically and internationally on topics in nutrition and functional endocrinology.  She has had the privilege of visiting Medi-Herb in Australia for 3 years to receive advanced training in phytotherapy.  She also had the honor to speak on alternative approaches to Metabolic Syndrome at the 2014 International Health Management Forum in Bejing China. Use the audio player above to listen now! And don’t forget to follow and like our podcast channel to stay up-to-date on upcoming episodes. Highlights of the episode include: Female hormones and stress sensitivity Adrenal burnout and perimenopause: the resiliency of the stress response affects hormone balance How herbs modulate and synergize with hormones Podcast Summary 2:24 Female hormones and stress sensitivity 4:00 The HPA Axis and the stress response 5:35 The thyroid adrenal connection 7:57 Cortisol, DHEA and the adrenal cortex 9:15 Prolactin, dopamine and high prevalence of autoimmunity in women 11:30 Key differences in male and female hormones: estradiol, testosterone, and DHEA 15:27 Peri- and menopausal hormone shifts 16:33 Adrenal burnout and perimenopause: the resiliency of the stress response affects hormone balance 21:13 Clinical strategies for adrenal support to mitigate perimenopausal symptoms – diet, exercise, sleep, digestion, and mental health 25:42 Herbs for adrenal support and endocrine balance – rehmania, ashwagandha, chaste tree, schizandra and more 29:33 How herbs modulate and synergize with hormones 30:02 Social media trends – perspectives on ashwagandha 33:06 Why guidance from a healthcare provider with herbal knowledge matters – finding the right herbs for each person 35:35 Choosing the right herb – how patient health history and symptom picture inform herbal selection 44:39 Using blood chemistry to inform patient protocols 45:55 Personalizing herbal protocols for different stages of the lifespan 48:38 Nutrients and herbs for libido and vaginal dryness and how adrenal resilience plays a role in these symptoms 50:32 Circulation, sexual health, and blood-flow support 52:53 Improving vasodilation through nitric oxide; whole foods and herbs that support circulation (beets, mountain spinach, red algae, and more) 54:45 Herbs as modulators – herbs won’t increase or decrease hormones too much 55:16 The truth about wild yam creams 58:54 The practitioner-patient journey – navigating better health together 1:01:51 Key clinical takeaway for supporting women’s health and stress management – how to build a good foundation and never lose sight of what you’re trying to build This podcast is sponsored by Standard Process About Standard Process – Only at SP https://youtu.be/06W6QnbDbSU?si=HhkXX9NerHPbhcDu

Physiology Meets Phytotherapy Any stressful situation, whether it is a family emergency, the deadline for a project, fear about losing a job, worry about not paying the bills on time, can trigger a cascade of signals in the body that release specific hormones that cause physiological changes in the body. This is known as the “fight” or “flight” response. These changes can manifest as a rapid heartbeat, sweat, tense muscles, headache, digestive problems, elevated body temperature, and more. Stress is the response to a real or perceived threat that disrupts the body’s homeostasis. The acute stress response is essential for survival, however, when the acute stress response is not shut off, there can be significant long-term health ramifications. As this acute response becomes prolonged, stress shifts from an adaptive reaction to a chronic condition. Chronic Stress and the HPA Axis Chronic stress occurs when there is prolonged exposure to stressful situations. This can be caused by long-term issues such as health problems, relationship issues, and problems at work. Overstimulation from technology and smart phones also contributes significantly to the overall increase in the experience of stress. Anxiety disorders have seen an 18.2% increase from 1990 to 2021 globally.1 Following Covid, over half of the population experienced emotional stress in 20 countries, and 85% of the countries reported worse psychological stress in 2020 compared with 2008.2 Chronic stress over time can wreak havoc in the body on your neurological health, hormone balance, and physical and mental health. Over time, this chronic stress can lead to Hypothalamic-Pituitary-Adrenal (HPA) axis dysfunction. The HPA axis consists of: Hypothalamus – the part of the brain responsible for regulating temperature, hunger mood, and more. It influences the autonomic nervous system and manages hormones. Pituitary gland – small gland located on the base of the brain below the hypothalamus. It makes essential hormones needed for the body and regulates other endocrine glands. Adrenal glands – small triangular shaped glands on the top of each kidney. They produce hormones like cortisol, aldosterone, and androgens that regulate blood pressure, stress response, metabolism, immune system, and sexual health. The adrenal glands also produce Epinephrine (the hormone that prepares the body for the flight or fight response) and norepinephrine. Cortisol Cortisol is a steroid hormone produced by the adrenals that is crucial to survival. It helps the body respond to stress, regulate blood sugar, metabolism, hormone regulation, and maintain blood pressure. The body is constantly producing, in varying concentrations throughout a 24-hour cycle. Typically, it is produced in higher amounts or stays elevated in those with a heightened fight/flight response. When cortisol levels rise significantly, it signals the hypothalamus to reduce the release of corticotrophin releasing hormone (CRH), which then leads to decreased ACTH production by the pituitary gland. High cortisol can inhibit and decrease production of other hormones like estrogen and progesterone which can lead to menstrual irregularities. Naturally cortisol levels should fluctuate throughout the day, being higher in the mornings and lower in the evenings. In the evenings, the body will produce melatonin and decrease cortisol production to facilitate a more restful state. In cases of chronic stress, cortisol can stay elevated for longer periods of time, and its patterns become more irregular. Herbal Remedies for Chronic Stress Given these physiological consequences, addressing chronic stress requires interventions that support both the nervous system and endocrine system. Herbal medicine can provide tremendous relief for those that experience acute or chronic stress. Numerous herbs have been utilized traditionally and effectively for managing both stress and anxiety. Herbs can be broken down into multiple therapeutic areas. Adaptogens Adaptogens, a term coined in the 1940’s, improve the body’s non-specific resistance to stress.3 Adaptogens accomplish this through their abilities to reduce oxidative stress, protect the mitochondria, normalize cortisol levels, and by regulating the HPA axis. Several adaptogens, including astragalus (Astragalus membranaceous), ashwagandha (Withania somniferum), licorice (Glycyrrhiza glabra), and rhodiola (Rhodiola rosea), have a long history of use in traditional herbal medicine for improving resilience to chronic stress, and have been shown in modern research to address multiple aspects of the stress response and more. Nervines Nervines are a category of plants that help to support the nervous system by relieving stress and helping to promote relaxation.4 Nervines, including lavender (Lavandula), skullcap (Scutellaria lateriflora), passionflower (Passiflora) and valerian (Valeriana officinalis) are plants that help to support the nervous system by relieving stress and promoting relaxation. Nervines are commonly used in conjunction with adaptogens due to the overlapping benefits. These work by acting on the central nervous system and peripheral nervous system to help improve overall resilience to stress.5 Nervines are categorized by nervine tonics, nervine relaxants, and nervine stimulants. Nervines typically have a fast-acting effect on the nervous system, making them more appropriate for addressing acute stress, while adaptogens work at a deeper level to support nervous system homeostasis. Nervine Spotlight on Skullcap Within these categories, several herbs stand out for their synergistic potential. Skullcap (Scutellaria Lateriflora), commonly known as “blue skullcap” and “American skullcap” is hardy perennial herb that belongs to the mint family (Lamiaceae), and is native to North America. Its traditional uses dates to the Indigenous people of North America who traditionally consumed it as a tea to help soothe nerves, as a sedative, and anticonvulsant.6 Today in western herbal medicine, skullcap is utilized to help relieve nervous tension, anxiety, combat insomnia, neuralgia, and epilepsy.7 Skullcap aerial parts consist of phytochemicals like flavonoids, glycosides, cinnamic acid and caffeic acid.6 Skullcap acts as a nervine tonic, spasmolytic and in higher doses, a sedative. It can have restorative effects on the nerves, physically and mentally/emotionally.  One study summarized key findings of a significant sleep-wake balance improvement when supplemented with Skullcap in a controlled, randomized, crossover double blind clinical trial.8 Adaptogenic Actions of Licorice Transitioning from nervines to adaptogens, licorice root is an adaptogen that has historically been used forbronchitis, throat infections, liver diseases, gastritis, peptic ulcerations, and adrenal insufficiency.7,9 It has a long history of use in traditional Asia and European herbal medicine and has since been commercially grown all over the world due to its multitude of uses in food, cosmetics, and pharmaceuticals.10 Transitioning from nervines to adaptogens, licorice root is an adaptogen that has historically been used forbronchitis, throat infections, liver diseases, gastritis, peptic ulcerations, and adrenal insufficiency.7,9 It has a long history of use in traditional Asia and European herbal medicine and has since been commercially grown all over the world due to its multitude of uses in food, cosmetics, and pharmaceuticals.10 Licorice’s main medicinal properties act as an anti-inflammatory, expectorant, demulcent, anti-microbial, and adrenal tonic. Licorice’s main key constituents consist of: saponins, glycyrrhizin (glycyrrhizic acid) present in the form of potassium and calcium salts and flavonoids.7 In animal models, licorice root was studied and noted to reduce anxiety and fear in post-traumatic stress disorder subjects.11 Glycyrrhizin from licorice root has been shown to contain antioxidant, anti-inflammatory, and immune regulatory actions.12 Adaptogen Spotlight on Ashwagandha Another cornerstone adaptogen, ashwagandha, has a long historical use as an adaptogen to strengthen the nervous system and combat stress. Ashwagandha holds therapeutic properties as a mild sedative, anti-inflammatory, immune modulating, neuroprotective, and anti-microbial.13 Its medicinal uses trace back to Indian medicine over 3,000 years ago.14 Traditionally, it has been used as an aphrodisiac, narcotic, tonic, diuretic, anthelmintic, and stimulant. It is naturally native in India but due to its current widespread popularity, it is now grown in many parts of the world.15 Another cornerstone adaptogen, ashwagandha, has a long historical use as an adaptogen to strengthen the nervous system and combat stress. Ashwagandha holds therapeutic properties as a mild sedative, anti-inflammatory, immune modulating, neuroprotective, and anti-microbial.13 Its medicinal uses trace back to Indian medicine over 3,000 years ago.14 Traditionally, it has been used as an aphrodisiac, narcotic, tonic, diuretic, anthelmintic, and stimulant. It is naturally native in India but due to its current widespread popularity, it is now grown in many parts of the world.15 Ashwagandha contains withanolides, alkaloids, and flavonoids.13 A recent study displayed that ashwagandha root extract may help improve sleep quality and sleep onset latency in patients with insomnia.16 Multiple studies have found that standardized ashwagandha root extracts reduce perceived stress, anxiety and lower cortisol when compared to placebos.16-18  Recent trials have shown improvements in endurance, strength and recovery in healthy adults and athletes using specific ashwagandha extract formulations. 19 Korean Ginseng as Adaptogen and Tonic Herb Korean ginseng has been traditionally used for athletic and psychomotor performances, depression, and sexual function.7 Its main actions include: adaptogenic, tonic, immune modulating, cardiotonic, male tonic, cancer preventative, and cognition enhancing.7 The key constituents of ginseng include a complex mixture of saponins, ginsenosides, oleanolic saponin, polysaccharides, and essential oils. Korean ginseng has been traditionally used for athletic and psychomotor performances, depression, and sexual function.7 Its main actions include: adaptogenic, tonic, immune modulating, cardiotonic, male tonic, cancer preventative, and cognition enhancing.7 The key constituents of ginseng include a complex mixture of saponins, ginsenosides, oleanolic saponin, polysaccharides, and essential oils. Ginsenosides, the main phytochemical of ginseng, has been studied for its anti-inflammatory and antioxidant properties in cell and animal models by modulating NF-kB and JAK/STAT pathways.20 Several small, randomized controlled trials found modest improvements in attention and working memory.21 Additional studies have been conducted to study ginseng and its role in fatigue, physical performance, and its cardiometabolic effects.22,23 Clinical Takeaways Chronic stress represents one of the most pervasive disruptors of physiological balance, influencing the HPA axis, hormone regulation, and overall neurological resilience. A combination of nervines and adaptogens offers a powerful therapeutic strategy. Nervines such as skullcap provide rapid relief of nervous tension, calming the hyperactive sympathetic response and promoting relaxation, while adaptogens like Ashwagandha, licorice root, and Korean ginseng, work more deeply to restore HPA axis function, regulate cortisol, and build long-term resilience to stress. In a clinical setting, this synergistic partnership allows for both immediate soothing of the nervous system and gradual rebalancing of hormonal and metabolic function. Together, these herbs bridge acute symptom relief with long-term adaptation, offering a holistic, evidence-informed approach to managing modern stress in all its physiological and psychological challenges.   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Turnip greens come from the leaves of root vegetable Brassica rapa subsp. rapa and are a particularly rich source of vitamins K, E, and B6 as well as plant form folate and phytoactive compound lutein. The dry leaves from turnips are also a rich source of glucosinolates and the activating enzyme myrosinase. Key Nutrients in Turnip Greens Percentages shown as %DV per serving of 5.68g turnip greens. Total Phenolic Concentration in Turnip Greens Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Turnip Greens Glucosinolates Sulfur-containing secondary metabolites mostly found in cruciferous vegetables, when activated by myrosinase from the plant or after ingestion by gut bacteria, associated with positive effects stemming from antioxidant activity such as cardio-protection and detoxification support Other Glucosinolates (4.12 mg/g)** Neoglucobrassicin (1.74mg/g)** Glucoraphasatin (1.2 mg/g)** Glucobrassicanapin (1.06 mg/g)** Flavonols Promote antioxidant activity and vascular health Kaempferol (31.7 mcg/g)* Quercetin (4.9 mcg/g)* Phenolic Acids Phytoactive compounds that promote anti-oxidant activity and vascular health Caffeic Acid(29.5 mcg/g)* Gallic Acid (23.1 mcg/g)* Ferulic Acid (6.0 mcg/g)* Protocatechuic Acid (6.0 mcg/g)* Myrosinase Enzyme found in plant tissue that initiates conversion of glucosinolates to bioactive isothiocyanates Ellagic Acid Potential antioxidant compound with anti-cancer potential Chloryphyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Carotenoids Antioxidants with anti-cancer potential and may lower risk of macular degeneration Beta-carotene(220.8 mcg/g)** *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Dark leafy greens with vibrantly colored stems and veins are trademark features of Swiss chard (Beta vulgaris subsp. cicla). This plant is a mineraldelivery powerhouse. Key Nutrients in Swiss Chard Percentages shown as %DV per serving of 5g dry Swiss chard extract. Total Phenolic Concentration in Swiss Chard Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Swiss Chard Chlorophyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Flavonols Promote antioxidant activity and vascular health Kaempferol(92 mcg/g)* Quercetin(75 mcg/g)* Myricetin(22 mcg/g)* Lignans Cross-linked phenolic compounds that make up plant cell walls and are insoluble fibers that aid in fecal bulking and feed some gut bacteria Secoisolariciresinol   (0.07 mcg/g)* Betalains Natural pigments with antioxidant, anti-cancer, anti-lipidemic, and antimicrobial properties Betacyanins Betaxanthins Carotenoids Antioxidants with anti-cancer potential and may lower risk of macular degeneration Lutein  (1.45 mg/g)** Zeaxanthin(10.6 mg/g)** Beta-carotene (52.26 mg/g)** *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Spanish Black Radish (Raphinoussativus L. Var. niger) is a cruciferous vegetable associated with the production of detoxification enzymes, healthy digestion, and healthy liver and gallbladder function. Spanish black radish is grown for its rich supply of glucosinolates. Key Nutrients in Spanish Black Radish Percentages shown as %DV per serving of 5.5g Spanish black radish. Total Phenolic Concentration in Spanish Black Radish Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Spanish Black Radish Glucosinolates Sulfur-containing secondary metabolites mostly found in cruciferous vegetables, when activated by myrosinase from the plant or after ingestion by gut bacteria, associated with positive effects stemming from antioxidant activity such as cardio-protection and detoxification support Glucobrassicin (11.835 mg/g)** Sinigrin (0.215 mg/g)** Gluconapin (0.2 mg/g)**Glucoraphanin (0.12 mg/g)** Glucoerucin (0.095 mg/g)** Glucobrassicin (0.082 mg/g)** Glucobrassicanapin (0.058 mg/g)**Glucoraphenin (0.004 mg/g)** Neoglucobrassicin (0.002 mg/g)**4-MeOH Glucobrassicin (0.002 mg/g)** Saponins Compounds that support the immune system, healthy cholesterol levels, and blood glucose levels Tanins Large set of diverse phenolic compounds found in plants that contribute to antioxidant activity, antimicrobial action, and distinct dark color  Myrosinase Enzyme found in plant tissue that initiates conversion of glucosinolates to bioactive isothiocyanates Fiber Supports cardiovascular health, healthy bowel function, and healthy cholesterol levels *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

The squeezed juice from the combined pods, vines, leaves, and stems of the common pea (Pisum sativum) is a nutritionally packed source of essentialvitamins and a significant source for phenolic compounds. Key Nutrients in Peavine Percentages shown as %DV per serving of 5g peavine juice extract. Total Phenolic Concentration in Peavine Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Peavine Chlorophyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Flavonols Phenolic acids exclusive to oats with antioxidant and anti-inflammatory activities and a bitter perception Kaempferol Catechin (0.1 mcg/g)*Epicatechin (0.1 mcg/g)* Epigallocatechin Gallocatechin Lignans Large plant polyphenolic compounds that bypass human digestion, feed gut bacteria, and provide antioxidant activity Lariciresinol (0.5 mcg/g)* Pinoresinol (0.07 mcg/g)* Syringaresinol (0.04 mcg/g)*  Medioresinol (0.035 mcg/g)* Secoisolariciresinol (0.00756 mcg/g)* Phenolic Acids Compounds that promote antioxidant activity and vascular health Sinapoyl-glucoside Saponins Support the immune system, healthy cholesterol levels, and blood glucose levels Soyasaponin I Soyasaponin ßg Carotenoids Antioxidants with anti-cancer potential and may lower risk of macular degeneration Lutein (7.22 mcg/g)** Zeaxanthin (0.39 mcg/g)** *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

Oats (Avena sativa) are a widely consumed grain product as a rolled whole oat or ground into flour. They deliver a healthy source of energy paired with phenolic compounds, essential nutrients, soluble and insoluble fibers. Intake of soluble fibers from grain oats has been linked to reduced risk of cardiovascular disease (CVD). Top oat varieties include increased levels of phytochemicals and provide beneficial fibers.  Key Nutrients in Oats Percentages shown as %DV per serving of 30g oats. Total Phenolic Concentration in Oats Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Oats Fiber Supports cardiovascular health, healthy bowel function, and healthy cholesterol levels Beta-glucan (56 mcg/g)**  The main soluble fiber in oats connected to reduced CVD risk Arabinoxylan Type 1 Resistant Starch  Avenanthramides Phenolic acids exclusive to oats with antioxidant and anti-inflammatory activities and a bitter perception Avenanthramide C (49.24 mcg/g)* Avenanthramide B (31.85 mcg/g)* Avenanthramide A (31.67 mcg/g)* Avenanthramide E (0.15 mcg/g)* Lignans Large plant polyphenolic compounds that bypass human digestion, feed gut bacteria, and provide antioxidant activity Syringaresinol (3.5 mcg/100g)*  Lariciresinol (1.8 mcg/100g)* Matairesinol (0.7 mcg/100g)*Medioresinol (0.4 mcg/100g)* Secoisolariciresinol (0.1 mcg/100g)* Pinoresinol (0.08 mcg/100g)* Phenolic Acids Compounds that promote antioxidant activity and vascular health 4-Hydrobenzoic Acid  (4.5 mcg/g)* Vanillic Acid  (2.7 mcg/100g)* Ferulic Acid (1.9 mcg/100g)* p-Coumaric Acid  (1.6 mcg/100g)* Hydrobenzaldehyde (1.2 mcg/100g)* Sinapic Acid (0.4 mcg/100g)* Flavanones Colorless flavonoid compounds with antioxidant activity Neohesperidin (6.2 mcg/g)* Saponins Support the immune system, healthy cholesterol levels, and blood glucose levels Avenacoside A Avenacoside B *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More

The material of the common bean (Phaseolus vulgaris) is rich with iron, magnesium, folate, fiber, and thiamin, among other macro- and micronutrients. The sprouts and full-grown plant contain ample amounts of essential minerals, various vitamins, and phenolic compounds. Key Nutrients in Kidney Bean Percentages shown as %DV per serving of 5g kidney bean juice extract. Total Phenolic Concentration in Kidney bean Measured: Total Phenolics as Gallic Acid Equivalence (mg/g). Phytoactives in Kidney Bean Saponins Support the immune system, healthy cholesterol levels, and blood glucose levels Bayogenin Soyasaponin I Soyasaponin V Chlorophyll Green pigment in plants with potential anti-inflammatory, antioxidant, and anti-bacterial activity  Lignans Large plant polyphenolic compounds that bypass human digestion, feed gut bacteria, and provide antioxidant activity Lariciresinol (1.2 mcg/g)* Secoisolariciresinol (0.8 mcg/g)* Pinoresinol (0.3 mcg/g)* Syringaresinol (0.08 mcg/g)*  Phenolic Acids Compounds that promote antioxidant activity and vascular health Ferulic Acid (128.4 mcg/g)* Sinapic Acid (51.7 mcg/g)* p-Coumaric Acid  (38.1 mcg/g)* Coumaroyl-malate Feruroyl-malate Isoflavonoids Phenolic compounds with direct antioxidant effects Genistein (2.0 mcg/g)* Flavonols Promote antioxidant activity and vascular health Kaempferol-3-O-glucoside (398.8 mcg/g)* Quercetin-3-glucoronide2(286 mcg/g)* Kaempferol-3-O-acetyl-glucoside (164 mcg/g)* Kaempferol-3-O-xylosyl-glucoside (115 mcg/g)* Kaempferol (12.2 mcg/g)*Quercetin (6.8 mcg/g)* Kaempferol-3-glycoside Kaempferol-3-O-rutinoside Quercetin-3-acetyl-glycoside Quercetin-3-glycoside Rutin *Data is mean values from Phenol-Explorer Database1 **Data on file with WholisticMatters. Values subject to change based on strain and experimental methods   Did you know WholisticMatters is powered by Standard Process? Learn more about Standard Process’ whole food-based nutrition philosophy.   Learn More