Phellodendron bark, golden seal, Oregon grape, and many other herbs have something in common: berberine, a natural substance associated with antimicrobial effects. In addition to this natural substance, Phellodendron bark also contains other phytoactive compounds like phenolics and flavonoids.

As a result of its profile of beneficial components, Phellodendron bark has long been used for conditions like dysentery, intestinal worms, and jaundice. Many clinical studies have recorded the beneficial effects seen as a result of berberine intake via herbs like Phellodendron bark.

In a human study, researchers saw improvements in microbial profiles in type 2 diabetics after eight weeks of berberine supplementation. Many studies associated this substance with positive therapeutic effects on individuals with acute infectious diarrhea and Clostridium difficile infection. Various studies have also linked berberine to improvements in irritable bowel syndrome and other gastrointestinal conditions, heart disease, and metabolic syndrome.

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