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Scientific Name: Lycopus virginicus

Constituents:

  • Phenolic acid derivatives (caffeic, rosmarinic, euroabienol, chlorogenic, ellagic & luteolin)
  • Volatile oil
  • Bitter principle
  • Manganese

Medicinal actions:

  • Anti-hyperthyroid
  • Astringent
  • Bitter
  • Diuretic
  • Nervine relaxant
  • Peripheral vasoconstrictor

Mechanism of Action & Pharmacology:

  • Phenolic compounds may decrease LH, inhibit TSH from binding to the thyroid, and inhibit peripheral T4 conversion to T3 by liver cells, presumably as a consequence of a reduced peripheral T4 deiodination.
  • Inhibits iodine metabolism and thyroxine release from the thyroid gland.
  • Rosmarinic acid, luteolin, and euroabienol appear responsible for antimicrobial effects.

Pharmacy:

  • Tincture
  • Capsules
  • Note: alcohol extract appears to be the most efficacious preparation as it maximizes the amount of phenolic compounds (constituents associated with the anti-thyroid activity)

Safety & Toxicity Concerns:

  • Avoid in Hypothyroidism, pregnancy & lactation.

Interactions:

  • May interfere with thyroid hormones and/or radioactive iodine by altering the regulatory metabolism of thyroid hormones (theoretical).
  • Radioactive iodine may interfere with administration of diagnostic procedures using radioactive isotopes.
  • Thyroid hormones should not be administered concurrently with preparations containing thyroid hormone.

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