Medicinal Herbs and ADHD


2′-FL’s Unique Decoy Binding Mechanism

Key Topics: Digestive Health
July 22, 2020
BookmarkBookmark bookmark Share

Notice: Undefined variable: fbIcon in /home/ndc9e95/public_html/wp-content/themes/wholisticmatters/includes/functions.php on line 218

About this PDF

2’-fucosyllactose (2’-FL), is a human milk oligosaccharide (HMO), a type of prebiotic found in breast milk. 2′-FL has a unique decoy binding mechanism and is associated with a healthy influence on the gut microbiome when consumed. Like other prebiotics, 2′-FL delays metabolization until it reaches the lower gastrointestinal (GI) tract, where it can “feed” beneficial microbes in the gut microbiome. The best part? 2′-FL is a selective food source, and only certain gut bacteria – “good” bacteria – can utilize it for energy. One of these bacterial species is Bifidobacteria.

One of 2′-FL’s unique capabilities, in addition to providing nourishment for good bacteria in the gut microbiome, is its decoy binding mechanism. 2′-FL’s structure closely resembles that of surface sugars on intestinal cells of the GI tract. External pathogens may enter the GI tract, bind to these surface sugars, and begin an infection, triggering inflammation of the gut, subsequent, undesirable symptoms, and potential long-term compositional changes in the microbiome. However, because of 2′-FL’s close resemblance to these surface sugars, 2′-FL serves as a “decoy,” binding external pathogens to prevent attachment to intestinal cells and the onset of infection.

Infants are born with a certain amount of bacteria in the gut microbiome, so HMOs like 2′-FL are important dietary contributors through breastfeeding. 2′-FL supports a growing microbiome by promoting the thriving populations of healthy gut microbes like Bifidobacteria. 2′-FL can also support a healthy gut microbiome for adults in times of GI stress and for Bifidobacteria-deficient individuals looking for increasing microbiome diversity.

Watch the animation.

Scientifically driven. Education focused. Healing Inspired.

Subscribe to Insights

Receive clinically driven nutrition insights you can trust.

Animated Newsletter WM

Join Our Community to Read Further

This is a premium article created for our Healthcare Practitioner readers. Create a free account to continue reading and gain full access.



WholisticMatters offers health care practitioners and nutrition enthusiasts alike the opportunity to create a free profile for access to site features like bookmarking. Enjoying an article you are reading or a video you are watching? Save it to come back to later! Sign up in seconds for continuous access to all that WholisticMatters has to offer.

WholisticMatters also offers health care practitioners who create a free user profile access to exclusive content and tools to utilize in clinical practice. Articles, tools, and downloads created specifically for practitioners to use in their office for better patient education in clinical nutrition and health. Sign up today with your email and credentials so we can confirm you as a health care practitioner, and you are free to peruse the resources unique to you and your colleagues in health.


Create Your Account:

show-pass Please use 8 or more characters with a mix of letters, numbers & symbols

Create a free account to use our great bookmarking tool

Once your account is created, you'll be able to save and organize what matters to you!

Already have an Account? Login Here

Click 'Sign Up' above to accept Wholistic Matters's Terms of Service & Privacy Policy.

Are you a Healthcare Professional? Sign Up For Free Access!

We'll verify your credentials and get you access to our great interactive tools.

Already have an Account? Login Here

Click 'Sign Up' above to accept Wholistic Matters's Terms of Service & Privacy Policy.