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Scientific Name: Passiflora incarnata

Constituents:

  • Indole alkaloids (harman & harmoline)
  • Flavonoids (Chrysin, vitexin, isovitxein, homoorientin, orientin, rutin, kaempferol & quercitin)
  • Fatty acids (linoleic, linolenic, palmitic, oleic, myristic)
  • Acids (formic & butyric)
  • Coumarins
  • Cyanogenic glycosides
  • Volatile oil

Medicinal actions:

  • Analgesic
  • Antispasmodic
  • Bitter
  • Cardiotonic
  • Diuretic
  • Hypotensive
  • Nervine Relaxant & Sedative

Mechanism of Action & Pharmacology:

  • Alkaloids (harmoline) have muscle relaxant and sedative effects.
  • Flavonoids are antispasmodic, anti-inflammatory and sedative.
  • Chrysin may be responsible for anxiolytic effects mediated via modulation of the GABA system including affinity to GABA receptors, and effects on GABA re-uptake. In vitro effects of an extract showed modulation of the GABA system including affinity to GABA(A) and GABA(B) receptors.
  • Anti-hypertensive effects of extract may be due to the GABA-induced antihypertensive effect and partially to the vasodilatory effect of polyphenols including luteolin.

Pharmacy:

  • Infusion
  • Tincture
  • Capsules

Safety & Toxicity Concerns:

  • Possible mild nerve and muscle irritation with long-term use.

Interactions:

  • Additive effects with sleep aids, barbiturates and other CNS depressants.

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