Scientific Name: Passiflora incarnata
- Indole alkaloids (harman & harmoline)
- Flavonoids (Chrysin, vitexin, isovitxein, homoorientin, orientin, rutin, kaempferol & quercitin)
- Fatty acids (linoleic, linolenic, palmitic, oleic, myristic)
- Acids (formic & butyric)
- Cyanogenic glycosides
- Volatile oil
- Nervine Relaxant & Sedative
Mechanism of Action & Pharmacology:
- Alkaloids (harmoline) have muscle relaxant and sedative effects.
- Flavonoids are antispasmodic, anti-inflammatory and sedative.
- Chrysin may be responsible for anxiolytic effects mediated via modulation of the GABA system including affinity to GABA receptors, and effects on GABA re-uptake. In vitro effects of an extract showed modulation of the GABA system including affinity to GABA(A) and GABA(B) receptors.
- Anti-hypertensive effects of extract may be due to the GABA-induced antihypertensive effect and partially to the vasodilatory effect of polyphenols including luteolin.
- Infusion: 1 tsp/per cup, BID-TID.
- Tincture: (1:5, 40%), 1-3 ml TID. 40 ml weekly max.
- Capsules: 350 mg, BID, or 700 mg hs.
- Note: Pause 2 weeks on, 2 days off with long-term dosing.
Safety & Toxicity Concerns:
- Possible mild nerve and muscle irritation with long-term use.
- Additive effects with sleep aids, barbiturates and other CNS depressants.