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Scientific Name: Juglans nigra

Constituents:

  • Naphthaquinones (juglone & plumbagin)
  • Tannins (ellagic & gallic acids)
  • Volatile oil
  • Fatty acids
  • Flavonoids
  • Silica

Medicinal actions:

  • Alterative
  • Anti-parasitic
  • Antimicrobial (anti-fungal)
  • Anti-neoplastic
  • Astringent
  • Bitter
  • Laxative (stimulating)

Mechanism of Action & Pharmacology:

  • Naphthaquinones (juglone & plubagin) are anti-fungal, antimicrobial, anti-tumor and anti-parasitic, and have laxative effects.
  • In vitro studies indicate that plumbagin was larvicidal and inhibited the motility and hatching of parasitic larvae, as well as having anti-malarial effects.
  • Juglone inhibits the growth of oral cariogenic bacteria (Streptococcus mutans and Streptococcus sanguis) and periodontal pathogens (Porphyromonas gingivalis and Prevotella intermedia).
  • Tannins have astringent effects.

Pharmacy:

  • Tincture
  • Capsules
  • Pulse dosing

Safety & Toxicity Concerns:

  • Nausea, vomiting, and watery catharsis.
  • External application may cause dermatitis (treat by washing area with soap and water). Juglone may cause allergic reaction and genetic mutation with long-term use.
  • Chronic GIT conditions, pregnancy & lactation.

Interactions:

  • Theoretically may interfere with absorption of any drug when taken simultaneously due to laxative effects.

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