Scientific Name: Boswellia serrata
- Oleo-Resin (α- and β boswellic acids: tetra and Pentacyclic triterpene acids)
- Volatile oil (pinene, dipentene & phellandrene)
- Mucilage & Polysaccharides
Mechanism of Action & Pharmacology:
- Resin (Boswellic acids) have been shown to be specific non-redox and non-competitive inhibitors of 5-lipoxygenase, the key enzyme of leukotriene biosynthesis. In a dose-dependent manner these acids block the synthesis of pro-inflammatory 5-lipoxygenase products, including leukotriene B4 (LTB4), which cause bronchoconstriction, chemotaxis, and increased vascular permeability. Also shown effects on the immune system such as decreased cytokines (interleukins and TNF-α) levels and diminished complement system and leukocyte elastase activities, reduction of ROS formation and P-selectin-mediated recruitment of inflammatory cells.
Safety & Toxicity Concerns:
- High resin content may cause stomach upset.
- May theoretically interfere with the absorption of drugs.
- Boswellic acids may be best absorbed in the presence of bile acids. Consider dosing along with food.