Medicinal Herbs and ADHD

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Scientific Name: Arctium Iappa

Constituents:

  • Lignans (arctigenin, arctiin, Lappaol F & matairesinol)
  • Polysaccharides (up to 50% inulin) & Mucilage
  • Tannins
  • Sulphur containing polyacetylenes
  • Volatile oil (terpenoids)
  • Sesquiterpene lactones (arctiopicrin)
  • Nutrients (vitamins & minerals)
  • Flavonoids
  • Hydroxycinnamic acid derivatives

Medicinal actions:

  • Alterative
  • Anti-inflammatory
  • Antimicrobial
  • Antioxidant
  • Anti-tumorogenic
  • Bitter
  • Diuretic
  • Hepatic & Hepatoprotective
  • Hypoglycemic
  • Hypolipidemic
  • Immuno-stimulant
  • Laxative (mild)

Mechanism of Action & Pharmacology:

  • Polysaccharides (mucilage & inulin) are soothing to the digestive tract and an immunostimulant.
  • Sesquiterpene lactone arctiopicrin is a bitter glycoside and antibacterial.
  • Lignans (arctigenin) exhibits anti-inflammatory activities by inhibiting inducible nitric oxide synthase (iNOS) via modulation of several cytokines, and is gastroprotective. Lappaol F exhibits anti-tumor activity in vitro and in vivo and is considered to have strong potential to be developed as an anticancer therapeutic.

Pharmacy:

  • Decoction
  • Tincture
  • Fresh root as food
  • Note: Best used long-term

Safety & Toxicity Concerns:

  • None reported, although a gentle approach is advised since it can be a powerful detoxifier in some individuals.
  • Potential adverse reactions include dermatitis from topical use, and allergic sensitivity to Asteraceae family.
  • Use caution in history of bleeding disorder, dehydration, electrolyte imbalance, hypoglycemia, pregnancy & lactation, and in diabetes as may precipitate decrease in blood sugar.

Interactions:

  • Increases gut motility, thus may theoretically decrease absorption of medications taken simultaneously.
  • May potentiate aspirin or anticoagulants due to antiplatelet activity (theoretical).
  • Potential additive effects with anti-diabetic agents and diuretics.
  • May increase levels of CYP3A4 substrates.

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